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Volume 16, Issue 4 (Iranian Journal of Breast Diseases 2024)
ijbd 2024, 16(4): 21-33 |
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Alvandi Ashiani S, Mohamadynejad P. ER-NE T>C polymorphism in ESR1 gene promoter and increased risk of breast cancer. ijbd 2024; 16 (4) :21-33
URL: http://ijbd.ir/article-1-1062-en.html
URL: http://ijbd.ir/article-1-1062-en.html
1- Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
2- Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. , parisa_mohamadynejad@yahoo.com
2- Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. , parisa_mohamadynejad@yahoo.com
Abstract: (533 Views)
Introduction: A change in the expression of estrogen receptor α, as a key mediator of the response to estrogen in breast tissue, plays a role in the susceptibility to breast cancer. In the present study, the relationship between ER-NE T>C functional polymorphism (rs9478245) in the regulatory region of the ESR1 gene and the risk of breast cancer was investigated.
Methods: In this case-control study, the rs9478245 polymorphic genotype was determined by PCR-RFLP technique in 200 breast cancer patients and 172 healthy individuals. The collected data were analyzed in SPSS23 software using a logistic regression test with a significance level of p < 0.05.
Results: The results showed that allele C, as well as TC and CC genotypes of rs9478245 polymorphism, significantly increase the risk of breast cancer.
Conclusion: It seems that the ER-NE T>C functional polymorphism affects the susceptibility to breast cancer so that the C allele as a dominant allele increases the risk of breast cancer.
Methods: In this case-control study, the rs9478245 polymorphic genotype was determined by PCR-RFLP technique in 200 breast cancer patients and 172 healthy individuals. The collected data were analyzed in SPSS23 software using a logistic regression test with a significance level of p < 0.05.
Results: The results showed that allele C, as well as TC and CC genotypes of rs9478245 polymorphism, significantly increase the risk of breast cancer.
Conclusion: It seems that the ER-NE T>C functional polymorphism affects the susceptibility to breast cancer so that the C allele as a dominant allele increases the risk of breast cancer.
Type of Study: Research |
Subject:
molecular cell
Received: 2023/07/25 | Accepted: 2023/10/11 | Published: 2024/01/7
Received: 2023/07/25 | Accepted: 2023/10/11 | Published: 2024/01/7
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